Though it's set in Washington, DC, the movie was largely shot in Toronto, Canada. Thanks to Reel Toronto for identifying the Toronto locations.
Detective Regis (Wesley Snipes) stops a suicidal governmental employee - Indiana Avenue and 6th Street, NW, Washington, DC
Regis and his partner Steve Stengel (Dennis Miller) in a bar - Paddock Tavern, 178 Bathurst Street, Toronto, Ontario
Regis is called to investigate a murder at The White House, 1600 Pennsylvania Avenue, NW, Washington, DC
Regis' house - 42 Maitland Street, Toronto, Ontario
Regis attends a black-tie reception - Manulife Building, 200 Bloor Street East, Toronto, Ontario. The interiors were filmed at The Fairmont Royal York Hotel, 100 Front Street West, Toronto, Ontario.
Regis is waiting outside of a night club - Pearl Street at Duncan, Toronto, Ontario
Agent Chance (Diane Lane) goes to check the Secret Service Archives - Treasury Building, 1500 Pennsylvania Avenue, NW, Washington, DC. The interiors were filmed at City of Toronto Archives, 255 Spadina Road, Toronto, Ontario.
Regis and Chance secretly meet on the Rock Creek Parkway, Washington, DC
Regis confronts the President's son - Meridian Hill Park, Columbia Heights, Washington, DC
Pursued by Secret Service, agent Chance holes up at a motel - Hillcrest Motel, 2143 Lakeshore Boulevard West, Toronto, Ontario
Chance meets Regis at a diner - Garden Gate Restaurant, 2379 Queen Street East, Toronto, Ontario
Regis discusses the White House murder with the National Security Adviser (Alan Alda) - Tidal Basin path, Washington, DC
The house of the Secret Service Chief - Still searching for this location
Regis and Chance go to a Brack store to check the videotape they got from the Secret Service Chief. The store was located at 69 Front Street East, Toronto, Ontario (now closed.)
Regis, Chance and Stengel are trying to sneak into the White House tunnel system near the Washington Monument Snack Bar, the National Mall, Washington, DC
In the Line of Fire
No Way Out